Specific inactivation of two immunomodulatory SIGLEC genes during human evolution

Sialic acid-recognizing Ig-like lectins (Siglecs) are signaling receptors that modulate immune responses, and are targeted for interactions by certain pathogens. We describe two primate Siglecs that were rendered nonfunctional by single genetic events during hominin evolution after our common ancest...

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Detalhes bibliográficos
Main Authors: Wang, Xiaoxia, Mitra, Nivedita, Secundino, Ismael, Banda, Kalyan, Cruz, Pedro, Padler-Karavani, Vered, Verhagen, Andrea, Reid, Chris, Lari, Martina, Rizzi, Ermanno, Balsamo, Carlotta, Corti, Giorgio, De Bellis, Gianluca, Longo, Laura, Beggs, William, Caramelli, David, Tishkoff, Sarah A., Hayakawa, Toshiyuki, Green, Eric D., Mullikin, James C., Nizet, Victor, Bui, Jack, Varki, Ajit, Benjamin, Betty, Blakesley, Robert, Bouffard, Gerry, Brooks, Shelise, Chu, Grace, Coleman, Holly, Dekhtyar, Mila, Gregory, Michael, Guan, Xiaobin, Gupta, Jyoti, Han, Joel, Hargrove, April, Ho, Shi-ling, Johnson, Taccara, Legaspi, Richelle, Lovett, Sean, Maduro, Quino, Masiello, Cathy, Maskeri, Baishali, McDowell, Jenny, Montemayor, Casandra, Novotny, Betsy, Park, Morgan, Riebow, Nancy, Schandler, Karen, Schmidt, Brian, Sison, Christina, Stantripop, Mal, Thomas, James, Vemulapalli, Meg, Young, Alice
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382539/
https://ncbi.nlm.nih.gov/pubmed/22665810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119459109
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