Specific inactivation of two immunomodulatory SIGLEC genes during human evolution

Sialic acid-recognizing Ig-like lectins (Siglecs) are signaling receptors that modulate immune responses, and are targeted for interactions by certain pathogens. We describe two primate Siglecs that were rendered nonfunctional by single genetic events during hominin evolution after our common ancest...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Wang, Xiaoxia, Mitra, Nivedita, Secundino, Ismael, Banda, Kalyan, Cruz, Pedro, Padler-Karavani, Vered, Verhagen, Andrea, Reid, Chris, Lari, Martina, Rizzi, Ermanno, Balsamo, Carlotta, Corti, Giorgio, De Bellis, Gianluca, Longo, Laura, Beggs, William, Caramelli, David, Tishkoff, Sarah A., Hayakawa, Toshiyuki, Green, Eric D., Mullikin, James C., Nizet, Victor, Bui, Jack, Varki, Ajit, Benjamin, Betty, Blakesley, Robert, Bouffard, Gerry, Brooks, Shelise, Chu, Grace, Coleman, Holly, Dekhtyar, Mila, Gregory, Michael, Guan, Xiaobin, Gupta, Jyoti, Han, Joel, Hargrove, April, Ho, Shi-ling, Johnson, Taccara, Legaspi, Richelle, Lovett, Sean, Maduro, Quino, Masiello, Cathy, Maskeri, Baishali, McDowell, Jenny, Montemayor, Casandra, Novotny, Betsy, Park, Morgan, Riebow, Nancy, Schandler, Karen, Schmidt, Brian, Sison, Christina, Stantripop, Mal, Thomas, James, Vemulapalli, Meg, Young, Alice
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2012
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382539/
https://ncbi.nlm.nih.gov/pubmed/22665810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119459109
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