A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation

Uncontrolled activation of tumor necrosis factor receptor-associated factor (TRAF) proteins may result in profound tissue injury by linking surface signals to cytokine release. Here we show that a ubiquitin E3 ligase component, Fbxo3, potently stimulates cytokine secretion from human inflammatory ce...

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Hauptverfasser: Chen, Bill B., Coon, Tiffany A., Glasser, Jennifer R., McVerry, Bryan J., Zhao, Jing, Zhao, Yutong, Zou, Chunbin, Ellis, Bryon, Sciurba, Frank C., Zhang, Yingze, Mallampalli, Rama K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631463/
https://ncbi.nlm.nih.gov/pubmed/23542741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2565
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