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A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation
Uncontrolled activation of tumor necrosis factor receptor-associated factor (TRAF) proteins may result in profound tissue injury by linking surface signals to cytokine release. Here we show that a ubiquitin E3 ligase component, Fbxo3, potently stimulates cytokine secretion from human inflammatory ce...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3631463/ https://ncbi.nlm.nih.gov/pubmed/23542741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2565 |
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