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αC Helix as a Switch in the Conformational Transition of Src/CDK-like Kinase Domains

[Image: see text] One mechanism of regulating the catalytic activity of protein kinases is through conformational transitions. Despite great diversity in the structural changes involved in the transitions, a certain set of changes within the kinase domain (KD) has been observed for many kinases incl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Huang, He, Zhao, Ruijun, Dickson, Bradley M., Skeel, Robert D., Post, Carol Beth
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630996/
https://ncbi.nlm.nih.gov/pubmed/22448785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp301628r
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