Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing

Little is known about the processes that enable influenza A viruses to jump into new host species. Here we show that the non-structural protein1 nucleotide substitution, A374G, encoding the D125G(GAT→GGT) mutation, which evolved during the adaptation of a human virus within a mouse host, activates a...

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Bibliographic Details
Main Authors: Selman, Mohammed, Dankar, Samar K, Forbes, Nicole E, Jia, Jian-Jun, Brown, Earl G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630925/
https://ncbi.nlm.nih.gov/pubmed/26038410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emi.2012.38
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