Multifunctional Adaptive NS1 Mutations Are Selected upon Human Influenza Virus Evolution in the Mouse

The role of the NS1 protein in modulating influenza A virulence and host range was assessed by adapting A/Hong Kong/1/1968 (H3N2) (HK-wt) to increased virulence in the mouse. Sequencing the NS genome segment of mouse-adapted variants revealed 11 mutations in the NS1 gene and 4 in the overlapping NEP...

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Bibliografiska uppgifter
Huvudupphovsmän: Forbes, Nicole E., Ping, Jihui, Dankar, Samar K., Jia, Jian-Jun, Selman, Mohammed, Keleta, Liya, Zhou, Yan, Brown, Earl G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283688/
https://ncbi.nlm.nih.gov/pubmed/22363747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031839
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