Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence

BACKGROUND: To understand the evolutionary steps required for a virus to become virulent in a new host, a human influenza A virus (IAV), A/Hong Kong/1/68(H3N2) (HK-wt), was adapted to increased virulence in the mouse. Among eleven mutations selected in the NS1 gene, two mutations F103L and M106I had...

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Bibliographic Details
Main Authors: Dankar, Samar K, Wang, Shuai, Ping, Jihui, Forbes, Nicole E, Keleta, Liya, Li, Yishan, Brown, Earl G
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032709/
https://ncbi.nlm.nih.gov/pubmed/21226922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-8-13
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