Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30

BACKGROUND: The genetic basis for avian to mammalian host switching in influenza A virus is largely unknown. The human A/HK/156/1997 (H5N1) virus that transmitted from poultry possesses NS1 gene mutations F103L + M106I that are virulence determinants in the mouse model of pneumonia; however their in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dankar, Samar K, Miranda, Elena, Forbes, Nicole E, Pelchat, Martin, Tavassoli, Ali, Selman, Mohammed, Ping, Jihui, Jia, Jianjun, Brown, Earl G
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733596/
https://ncbi.nlm.nih.gov/pubmed/23886034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-243
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