The Sec7 Guanine Nucleotide Exchange Factor GBF1 Regulates Membrane Recruitment of BIG1 and BIG2 Guanine Nucleotide Exchange Factors to the Trans-Golgi Network (TGN)

Three Sec7 guanine nucleotide exchange factors (GEFs) activate ADP-ribosylation factors (ARFs) to facilitate coating of transport vesicles within the secretory and endosomal pathways. GBF1 recruits COPI to pre-Golgi and Golgi compartments, whereas BIG1 and BIG2 recruit AP1 and GGA clathrin adaptors...

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Main Authors: Lowery, Jason, Szul, Tomasz, Styers, Melanie, Holloway, Zoe, Oorschot, Viola, Klumperman, Judith, Sztul, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630886/
https://ncbi.nlm.nih.gov/pubmed/23386609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438481
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