Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells

It is known that microRNAs (miRs) are involved in lymphocyte development, homeostasis, activation, and occasionally malignant transformation. In this study, a miR-155 transgene (tg) was driven to be overexpressed off of the lck promoter in order to assess its effects on natural killer (NK) cell biol...

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Autori principali: Trotta, Rossana, Chen, Li, Costinean, Stefan, Josyula, Srirama, Mundy-Bosse, Bethany L., Ciarlariello, David, Mao, Charlene, Briercheck, Edward L., McConnell, Kathleen K., Mishra, Anjali, Yu, Lianbo, Croce, Carlo M., Caligiuri, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2013
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630828/
https://ncbi.nlm.nih.gov/pubmed/23422749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-467597
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