Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells

It is known that microRNAs (miRs) are involved in lymphocyte development, homeostasis, activation, and occasionally malignant transformation. In this study, a miR-155 transgene (tg) was driven to be overexpressed off of the lck promoter in order to assess its effects on natural killer (NK) cell biol...

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Detalhes bibliográficos
Main Authors: Trotta, Rossana, Chen, Li, Costinean, Stefan, Josyula, Srirama, Mundy-Bosse, Bethany L., Ciarlariello, David, Mao, Charlene, Briercheck, Edward L., McConnell, Kathleen K., Mishra, Anjali, Yu, Lianbo, Croce, Carlo M., Caligiuri, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630828/
https://ncbi.nlm.nih.gov/pubmed/23422749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-467597
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