The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

Interleukin-15 (IL-15) is essential for natural killer (NK) cell differentiation. In this study, we assessed whether the receptor tyrosine kinase Axl and its ligand, Gas6, are involved in IL-15–mediated human NK differentiation from CD34(+) hematopoietic progenitor cells (HPCs). Blocking the Axl-Gas...

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Autors principals: Park, Il-Kyoo, Giovenzana, Chiara, Hughes, Tiffany L., Yu, Jianhua, Trotta, Rossana, Caligiuri, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656272/
https://ncbi.nlm.nih.gov/pubmed/18840707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-157073
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