Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans

Defective lymphocyte apoptosis results in chronic lymphadenopathy and/or splenomegaly associated with autoimmune phenomena. The prototype for human apoptosis disorders is the autoimmune lymphoproliferative syndrome (ALPS), which is caused by mutations in the FAS apoptotic pathway. Recently, patients...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kuehn, Hye Sun, Niemela, Julie E., Rangel-Santos, Andreia, Zhang, Mingchang, Pittaluga, Stefania, Stoddard, Jennifer L., Hussey, Ashleigh A., Evbuomwan, Moses O., Priel, Debra A. Long, Kuhns, Douglas B., Park, C. Lucy, Fleisher, Thomas A., Uzel, Gulbu, Oliveira, João B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630827/
https://ncbi.nlm.nih.gov/pubmed/23430113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-469544
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados