Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans

Defective lymphocyte apoptosis results in chronic lymphadenopathy and/or splenomegaly associated with autoimmune phenomena. The prototype for human apoptosis disorders is the autoimmune lymphoproliferative syndrome (ALPS), which is caused by mutations in the FAS apoptotic pathway. Recently, patients...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kuehn, Hye Sun, Niemela, Julie E., Rangel-Santos, Andreia, Zhang, Mingchang, Pittaluga, Stefania, Stoddard, Jennifer L., Hussey, Ashleigh A., Evbuomwan, Moses O., Priel, Debra A. Long, Kuhns, Douglas B., Park, C. Lucy, Fleisher, Thomas A., Uzel, Gulbu, Oliveira, João B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2013
Gaiak:
Immunobiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630827/
https://ncbi.nlm.nih.gov/pubmed/23430113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-469544
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