Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is characterized by childhood onset of lymphadenopathy, hepatosplenomegaly, autoimmune cytopenias, elevated numbers of double-negative T (DNT) cells, and increased risk of lymphoma. Most cases of ALPS are associated with germline mutations of the FAS ge...

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Autori principali: Dowdell, Kennichi C., Niemela, Julie E., Price, Susan, Davis, Joie, Hornung, Ronald L., Oliveira, João Bosco, Puck, Jennifer M., Jaffe, Elaine S., Pittaluga, Stefania, Cohen, Jeffrey I., Fleisher, Thomas A., Rao, V. Koneti
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892951/
https://ncbi.nlm.nih.gov/pubmed/20360470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-263145
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