Distinct pathways for repairing mutagenic lesions induced by methylating and ethylating agents

DNA alkylation damage can be repaired by nucleotide excision repair (NER), base excision repair (BER) or by direct removal of alkyl groups from modified bases by O (6)-alkylguanine DNA alkyltransferase (AGT; E.C. 2.1.1.63). DNA mismatch repair (MMR) is also likely involved in this repair. We have in...

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Bibliographische Detailangaben
Hauptverfasser: Taira, Kentaro, Kaneto, Satomi, Nakano, Kota, Watanabe, Shinji, Takahashi, Eizo, Arimoto, Sakae, Okamoto, Keinosuke, Schaaper, Roel M., Negishi, Kazuo, Negishi, Tomoe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630523/
https://ncbi.nlm.nih.gov/pubmed/23446177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/get010
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