Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli

BACKGROUND: Chloroethylnitrosourea (CENU) derivatives, such as nimustine (ACNU) and carmustine (BCNU), are employed in brain tumor chemotherapy due to their ability to cross the blood-brain barrier. They are thought to suppress tumor development through DNA chloroethylation, followed by the formatio...

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Detalhes bibliográficos
Publicado no:Genes Environ
Main Authors: Yamada, Yoko, Watanabe, Shinji, Okamoto, Keinosuke, Arimoto, Sakae, Takahashi, Eizo, Negishi, Kazuo, Negishi, Tomoe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449902/
https://ncbi.nlm.nih.gov/pubmed/30988834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-019-0123-x
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