Mouse Oocyte Methylomes at Base Resolution Reveal Genome-Wide Accumulation of Non-CpG Methylation and Role of DNA Methyltransferases

DNA methylation is an epigenetic modification that plays a crucial role in normal mammalian development, retrotransposon silencing, and cellular reprogramming. Although methylation mainly occurs on the cytosine in a CG site, non-CG methylation is prevalent in pluripotent stem cells, brain, and oocyt...

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Detalhes bibliográficos
Main Authors: Shirane, Kenjiro, Toh, Hidehiro, Kobayashi, Hisato, Miura, Fumihito, Chiba, Hatsune, Ito, Takashi, Kono, Tomohiro, Sasaki, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630097/
https://ncbi.nlm.nih.gov/pubmed/23637617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003439
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