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Contribution of the M1 Transmembrane Helix and Pre-M1 Region to Positive Allosteric Modulation and Gating of N-Methyl-d-Aspartate Receptors

N-methyl-d-aspartate (NMDA) receptors are glutamate-gated ion channels whose function is critical for normal excitatory synaptic transmission in the brain and whose dysfunction has been implicated in several neurologic conditions. NMDA receptor function is subject to extensive allosteric regulation...

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Detalhes bibliográficos
Main Authors: Ogden, Kevin K., Traynelis, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629829/
https://ncbi.nlm.nih.gov/pubmed/23455314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.085209
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