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Role of the fourth transmembrane α-helix in the allosteric modulation of pentameric ligand-gated ion channels
The gating of pentameric ligand gated ion channels is sensitive to a variety of allosteric modulators that act on structures that are peripheral to those involved in the allosteric pathway leading from the agonist site to the channel gate. One such structure, the lipid-exposed transmembrane α-helix,...
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| Udgivet i: | Structure |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824752/ https://ncbi.nlm.nih.gov/pubmed/26235032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.06.020 |
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