Role of the fourth transmembrane α-helix in the allosteric modulation of pentameric ligand-gated ion channels

The gating of pentameric ligand gated ion channels is sensitive to a variety of allosteric modulators that act on structures that are peripheral to those involved in the allosteric pathway leading from the agonist site to the channel gate. One such structure, the lipid-exposed transmembrane α-helix,...

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Publicado en:Structure
Autores principales: Carswell, Casey L., Hénault, Camille M., Murlidaran, Sruthi, Therien, J.P. Daniel, Juranka, Peter F., Surujballi, Julian A., Brannigan, Grace, Baenziger, John E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824752/
https://ncbi.nlm.nih.gov/pubmed/26235032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.06.020
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