Intramembrane Aromatic Interactions Influence the Lipid Sensitivities of Pentameric Ligand-gated Ion Channels

Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be defined. Here, we examine th...

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Publicat a:J Biol Chem
Autors principals: Carswell, Casey L., Sun, Jiayin, Baenziger, John E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Membrane Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303698/
https://ncbi.nlm.nih.gov/pubmed/25519904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.624395
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