Hydroxylation of CYP11A1-Derived Products of Vitamin D3 Metabolism by Human and Mouse CYP27B1

CYP11A1 can hydroxylate vitamin D3 at carbons 17, 20, 22, and 23, producing a range of secosteroids which are biologically active with respect to their ability to inhibit proliferation and stimulate differentiation of various cell types, including cancer cells. As 1α-hydroxylation of the primary met...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Tang, Edith K. Y., Chen, Jianjun, Janjetovic, Zorica, Tieu, Elaine W., Slominski, Andrzej T., Li, Wei, Tuckey, Robert C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2013
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629803/
https://ncbi.nlm.nih.gov/pubmed/23454830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.050955
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