CYP2C9 promoter region single-nucleotide polymorphisms linked to the R150H polymorphism are functional suggesting their role in CYP2C9*8-mediated effects

Cytochrome P450 2C9 (CYP2C9) c.449G> A (*8) is common in African Americans and is associated with decreased warfarin clearance. We examined the effect of promoter region variants inherited with 449G > A on warfarin clearance, dose requirements, and CYP2C9 expression. In an African American coh...

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Autori principali: Cavallari, Larisa H., Vaynshteyn, David, Freeman, Kimberly M., Wang, Danxin, Perera, Minoli A., Takahashi, Harumi, Drozda, Katrzyna, Patel, Shitalben R., Jeong, Hyunyoung
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629689/
https://ncbi.nlm.nih.gov/pubmed/23376925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835e95c7
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