CTLA4-Ig immunosuppressive activity at the level of dendritic cell/T cell crosstalk

Immunosuppressive cytotoxic T lymphocyte associated antigen-4 immunoglobulin fusion proteins (CTLA4-Ig) block the CD28:CD80/86 costimulatory pathway. On a cellular level, CTLA4-Ig is understood to dampen T cell responses. As a mechanism, CTLA4-Ig has been reported to affect dendritic cell (DC) funct...

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Autors principals: Mayer, Edda, Hölzl, Markus, Ahmadi, Sarah, Dillinger, Barbara, Pilat, Nina, Fuchs, Dietmar, Wekerle, Thomas, Heitger, Andreas
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629566/
https://ncbi.nlm.nih.gov/pubmed/23434857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.intimp.2013.02.007
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