Indoleamine 2,3-dioxygenase (IDO) and Treg Support are Critical for CTLA4Ig-Mediated Long-term Solid Organ Allograft Survival

Co-stimulatory blockade of CD28-B7 interaction with CTLA4Ig is a well-established strategy to induce transplantation tolerance. Although previous in vitro studies suggest that CTLA4Ig up-regulates expression of the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) in dendritic cells, the rel...

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Detalhes bibliográficos
Main Authors: Sucher, Robert, Fischler, Klaus, Oberhuber, Rupert, Kronberger, Irmgard, Margreiter, Christian, Ollinger, Robert, Schneeberger, Stefan, Fuchs, Dietmar, Werner, Ernst R., Watschinger, Katrin, Zelger, Bettina, Tellides, George, Pilat, Nina, Pratschke, Johann, Margreiter, Raimund, Wekerle, Thomas, Brandacher, Gerald
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249458/
https://ncbi.nlm.nih.gov/pubmed/22131334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002777
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