Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells.

We have disrupted one allele of the N-myc locus in mouse embryonic stem (ES) cells by using homologous recombination techniques and have obtained germ line transmission of null N-myc ES cell lines with transmission of the null N-myc allele to the offspring. The creation of mice with a deficient N-my...

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Dettagli Bibliografici
Autori principali: Stanton, B R, Reid, S W, Parada, L F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1990
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC362953/
https://ncbi.nlm.nih.gov/pubmed/1701023
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