Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells.

Embryonic stem cells (derived from 129/Ola mice) containing a mutant hypoxanthine phosphoribosyltransferase gene that had been corrected in vitro in a planned manner by homologous recombination were injected into blastocysts obtained from C57BL/6J mice. The injected blastocysts were introduced into...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Koller, B H, Hagemann, L J, Doetschman, T, Hagaman, J R, Huang, S, Williams, P J, First, N L, Maeda, N, Smithies, O
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1989
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298403/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2573070/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.22.8927
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