TLR2 deletion promotes arthritis through reduction of IL-10

RA is a chronic inflammatory disease characterized by the persistent expression of inflammatory cytokines from macrophages, which may be mediated, in part, through TLR2 signaling. Earlier studies demonstrate a role for TLR2 signaling in dampening the arthritis in IL-1Ra−/− mice, which was mediated t...

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Bibliografske podrobnosti
Main Authors: Huang, Qi-Quan, Koessler, Renee E., Birkett, Robert, Perlman, Harris, Xing, Lianping, Pope, Richard M.
Format: Artigo
Jezik:Inglês
Izdano: Society for Leukocyte Biology 2013
Teme:
Inflammation, Extracellular Mediators, & Effector Molecules
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629443/
https://ncbi.nlm.nih.gov/pubmed/23446149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0912473
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