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ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10(−/−) mice

In the absence of IL-10, colonic inflammation ensues, which is characterized by high levels of IL-17. Here, we demonstrate a direct correlation between ICOS expression and IL-17 production in cIELs. IL-10(−/−) mice had increased numbers of cIELs and greater colon weight. Although the CD69 early acti...

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Main Authors: Schaefer, Jeremy S., Montufar-Solis, Dina, Vigneswaran, Nadarajah, Klein, John R.
Format: Artigo
Jezik:Inglês
Izdano: The Society for Leukocyte Biology 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812556/
https://ncbi.nlm.nih.gov/pubmed/19889730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0409238
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