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Deletion of Nrf2 impairs functional recovery, reduces clearance of myelin debris and decreases axonal remyelination after peripheral nerve injury

Oxidative stress is generated in several peripheral nerve injury models. In response to oxidative stress, the transcription factor Nrf2 is activated to induce expression of antioxidant responsive element (ARE) genes. The role of Nrf2 in peripheral nerve injury has not been studied to date. In this s...

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Autori principali: Zhang, Linxia, Johnson, Delinda, Johnson, Jeffrey A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628945/
https://ncbi.nlm.nih.gov/pubmed/23328769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.01.003
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