Reduced BACE1 Activity Enhances Clearance of Myelin Debris and Regeneration of Axons in the Injured Peripheral Nervous System

β-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is an aspartyl protease best known for its role in generating the amyloid-β peptides that are present in plaques of Alzheimer's disease. BACE1 has been an attractive target for drug development. In cultured embryonic neurons, BACE...

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Autors principals: Farah, Mohamed H., Pan, Bao Han, Hoffman, Paul N., Ferraris, Dana, Tsukamoto, Takashi, Nguyen, Thien, Wong, Philip C., Price, Donald L., Slusher, Barbara S., Griffin, John W.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302726/
https://ncbi.nlm.nih.gov/pubmed/21490216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6810-10.2011
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