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Resolution of Oligomeric Species during the Aggregation of Aβ(1-40) Using (19)F NMR

In the commonly used nucleation-dependent model of protein aggregation, aggregation proceeds only after a lag phase in which the concentration of energetically unfavorable nuclei reaches a critical value. The formation of oligomeric species prior to aggregation can be difficult to detect by current...

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Main Authors: Suzuki, Yuta, Brender, Jeffrey R., Soper, Molly T., Krishnamoorthy, Janarthanan, Zhou, Yunlong, Ruotolo, Brandon T., Kotov, Nicholas A., Ramamoorthy, Ayyalusamy, Marsh, E. Neil G.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628624/
https://ncbi.nlm.nih.gov/pubmed/23445400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400027y
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