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NMR Characterization of Monomeric and Oligomeric Conformations of Human Calcitonin and Its Interaction with EGCG

Calcitonin is a 32-residue peptide hormone known for its hypocalcemic effect and its inhibition of bone resorption. While calcitonin has been used in therapy for osteoporosis and Paget's disease for decades, human calcitonin (hCT) forms fibrils in aqueous solution that limit its therapeutic app...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Huang, Rui, Vivekanandan, Subramanian, Brender, Jeffrey R., Abe, Yuki, Naito, Akira, Ramamoorthy, Ayyalusamy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405540/
https://ncbi.nlm.nih.gov/pubmed/22200484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.023
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