Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2

Bone morphogenetic protein-2 (BMP-2) is a potent osteoinductive factor, yet its clinical use is limited by a short biological half-life, rapid local clearance and propensity for side effects. Heparin (HP), a highly sulfated glycosaminoglycan (GAG) that avidly binds BMP-2, has inherent biological pro...

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Bibliographic Details
Main Authors: Bhakta, Gajadhar, Rai, Bina, Lim, Zophia X.H., Hui, James H., Stein, Gary S., van Wijnen, Andre J., Nurcombe, Victor, Prestwich, Glenn D., Cool, Simon M.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628623/
https://ncbi.nlm.nih.gov/pubmed/22687758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.05.030
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