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Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2
Bone morphogenetic protein-2 (BMP-2) is a potent osteoinductive factor, yet its clinical use is limited by a short biological half-life, rapid local clearance and propensity for side effects. Heparin (HP), a highly sulfated glycosaminoglycan (GAG) that avidly binds BMP-2, has inherent biological pro...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3628623/ https://ncbi.nlm.nih.gov/pubmed/22687758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.05.030 |
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