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Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia

Notch regulates cell–cell contact-dependent signaling and is activated by hypoxia, a microenvironmental condition that promotes cellular invasion during both normal physiology and disease. The mechanisms by which hypoxia and Notch regulate cellular invasion are not fully elucidated. In this paper, w...

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Bibliografiske detaljer
Main Authors: Díaz, Begoña, Yuen, Angela, Iizuka, Shinji, Higashiyama, Shigeki, Courtneidge, Sara A.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628517/
https://ncbi.nlm.nih.gov/pubmed/23589494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201209151
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