Class IA PI3-kinase p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation

Autophagy is an evolutionarily conserved membrane trafficking process. Induction of autophagy in response to nutrient limitation or cellular stress occurs by similar mechanisms in organisms from yeast to mammals. Unlike yeast, metazoan cells rely more on growth factor signaling for a wide variety of...

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Autors principals: Dou, Zhixun, Pan, Ji-An, Dbouk, Hashem A., Ballou, Lisa M., DeLeon, Jennifer L., Fan, Yongjun, Chen, Juei-Suei, Liang, Zhimin, Li, Guangpu, Backer, Jonathan M., Lin, Richard Z., Zong, Wei-Xing
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628298/
https://ncbi.nlm.nih.gov/pubmed/23434372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.01.022
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