The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy

Autophagy is an evolutionarily conserved cell renewal process that depends on phosphatidylinositol 3-phosphate (PtdIns(3)P). In metazoans, autophagy is inhibited by PtdIns(3,4,5)P(3), the product of class IA PI3Ks, which mediates the activation of the Akt–TOR kinase cascade. However, the precise fun...

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Detalhes bibliográficos
Main Authors: Dou, Zhixun, Chattopadhyay, Mohar, Pan, Ji-An, Guerriero, Jennifer L., Jiang, Ya-Ping, Ballou, Lisa M., Yue, Zhenyu, Lin, Richard Z., Zong, Wei-Xing
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2983054/
https://ncbi.nlm.nih.gov/pubmed/21059846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201006056
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