Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314

QX-314 (N-ethyl-lidocaine) is a cationic lidocaine derivative that blocks voltage-dependent sodium channels when applied internally to axons or neuronal cell bodies. Coapplication of external QX-314 with the transient receptor potential vanilloid 1 protein (TRPV1) agonist capsaicin produces long-las...

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Bibliografiske detaljer
Main Authors: Puopolo, Michelino, Binshtok, Alexander M., Yao, Gui-Lan, Oh, Seog Bae, Woolf, Clifford J., Bean, Bruce P.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628012/
https://ncbi.nlm.nih.gov/pubmed/23303863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00012.2013
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