Predictive value of hypoxia, proliferation and tyrosine kinase receptors for EGFR-inhibition and radiotherapy sensitivity in head and neck cancer models

BACKGROUND AND PURPOSE: EGFR-inhibitor Cetuximab (C225) improves the efficacy of radiotherapy in only a subgroup of HNSCC patients. Identification of predictive tumor characteristics is essential to improve patient selection. MATERIAL AND METHODS: Response to C225 and/or radiotherapy was assessed wi...

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Hauptverfasser: Stegeman, Hanneke, Kaanders, Johannes H., van der Kogel, Albert J., Iida, Mari, Wheeler, Deric L., Span, Paul N., Bussink, Johan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627829/
https://ncbi.nlm.nih.gov/pubmed/23453541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2013.02.001
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