MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice

KRAS mutations are primary genetic lesions leading to pancreatic cancer. The promoter of human KRAS contains a nuclease-hypersensitive element (NHE) that can fold in G4-DNA structures binding to nuclear proteins, including MAZ (myc-associated zinc-finger). Here, we report that MAZ activates KRAS tra...

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Bibliographic Details
Main Authors: Cogoi, Susanna, Zorzet, Sonia, Rapozzi, Valentina, Géci, Imrich, Pedersen, Erik B., Xodo, Luigi E.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627599/
https://ncbi.nlm.nih.gov/pubmed/23471001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt127
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