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Increasing the Analytical Sensitivity by Oligonucleotides Modified with Para- and Ortho-Twisted Intercalating Nucleic Acids – TINA

The sensitivity and specificity of clinical diagnostic assays using DNA hybridization techniques are limited by the dissociation of double-stranded DNA (dsDNA) antiparallel duplex helices. This situation can be improved by addition of DNA stabilizing molecules such as nucleic acid intercalators. Her...

詳細記述

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書誌詳細
主要な著者: Schneider, Uffe V., Géci, Imrich, Jøhnk, Nina, Mikkelsen, Nikolaj D., Pedersen, Erik B., Lisby, Gorm
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108614/
https://ncbi.nlm.nih.gov/pubmed/21673988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020565
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