Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas

Seminoma is a subclass of human testicular germ cell tumors (TGCT), the most frequently observed cancer in young men with a rising incidence. Here we describe the identification of a novel gene predisposing specifically to seminoma formation in a vertebrate model organism. Zebrafish carrying a heter...

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Main Authors: Basten, Sander G., Davis, Erica E., Gillis, Ad J. M., van Rooijen, Ellen, Stoop, Hans, Babala, Nikolina, Logister, Ive, Heath, Zachary G., Jonges, Trudy N., Katsanis, Nicholas, Voest, Emile E., van Eeden, Freek J., Medema, Rene H., Ketting, René F., Schulte-Merker, Stefan, Looijenga, Leendert H. J., Giles, Rachel H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627517/
https://ncbi.nlm.nih.gov/pubmed/23599692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003384
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