Generation and screening of a large collection of novel simian Adenovirus allows the identification of vaccine vectors inducing potent cellular immunity in humans: A range of novel simian adenoviral vectors, which are capable of priming high levels of T cell responses in man, has been defined

Replication defective Adenovirus vectors based on the human serotype 5 (Ad5) have been shown to induce protective immune responses against diverse pathogens and cancer in animal models and to elicit robust and sustained cellular immunity in humans. However, most humans have anti-Ad5 neutralising ant...

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Main Authors: Colloca, Stefano, Folgori, Antonella, Ammendola, Virginia, Capone, Stefania, Cirillo, Agostino, Siani, Loredana, Naddeo, Mariarosaria, Grazioli, Fabiana, Esposito, Maria Luisa, Ambrosio, Maria, Sparacino, Angela, Bartiromo, Marta, Meola, Annalisa, Smith, Kira, Kurioka, Ayako, O’Hara, Geraldine A., Ewer, Katie J., Hill, Adrian V. S., Traboni, Cinzia, Barnes, Eleanor, Klenerman, Paul, Cortese, Riccardo, Nicosia, Alfredo
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627206/
https://ncbi.nlm.nih.gov/pubmed/22218691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002925
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