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Total Synthesis of 6-Deoxyerythronolide B via C-C Bond-Forming Transfer Hydrogenation

The 14-membered macrolide 6-deoxyerythronolide B is prepared in 14 steps (longest linear sequence) and 20 total steps. Two different methods for alcohol CH-crotylation via transfer hydrogenation are deployed for the first time in target-oriented synthesis. Enyne metathesis is used to form the 14-mem...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gao, Xin, Woo, Sang Kook, Krische, Michael J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625983/
https://ncbi.nlm.nih.gov/pubmed/23464668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4008722
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