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Total Synthesis of Bryostatin 7 via C-C Bond Forming Hydrogenation: Merged Redox-Construction Events for Synthetic Efficiency

The marine macrolide bryostatin 7 is prepared in 20 steps (longest linear sequence) and 36 total steps. A total of 5 C-C bonds are formed using hydrogenative methods. The present approach represents the most concise synthesis of any bryostatin reported, to date, setting the stage for practical synth...

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Hlavní autoři: Lu, Yu, Woo, Sang Kook, Krische, Michael J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164899/
https://ncbi.nlm.nih.gov/pubmed/21780806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja205673e
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