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Total Synthesis of (+)-Roxaticin via C-C Bond Forming Transfer Hydrogenation: A Departure from Stoichiometric Chiral Reagents, Auxiliaries and Premetallated Nucleophiles in Polyketide Construction
A total synthesis of the oxo-polyene macrolide (+)-roxaticin is achieved in 20 steps from 1,3-propanediol. In this approach, nine of ten C-C bonds formed in the longest linear sequence are made via metal catalysis, including 7 C-C bonds formed via iridium catalyzed alcohol C-C coupling. Notably, the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2975273/ https://ncbi.nlm.nih.gov/pubmed/20961111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1082798 |
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