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Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism
Circadian rhythms in mammals are generated by a transcriptional negative feedback loop that is driven primarily by oscillations of PER and CRY, which inhibit their own transcriptional activators, CLOCK and BMAL1. Current models posit that CRY is the dominant repressor while PER may play an accessory...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3625733/ https://ncbi.nlm.nih.gov/pubmed/19917250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.10.012 |
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