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Stoichiometric Relationship among Clock Proteins Determines Robustness of Circadian Rhythms
The mammalian circadian oscillator is primarily driven by an essential negative feedback loop comprising a positive component, the CLOCK-BMAL1 complex, and a negative component, the PER-CRY complex. Numerous studies suggest that feedback inhibition of CLOCK-BMAL1 is mediated by time-dependent physic...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044960/ https://ncbi.nlm.nih.gov/pubmed/21199878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.207217 |
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