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Stoichiometric Relationship among Clock Proteins Determines Robustness of Circadian Rhythms

The mammalian circadian oscillator is primarily driven by an essential negative feedback loop comprising a positive component, the CLOCK-BMAL1 complex, and a negative component, the PER-CRY complex. Numerous studies suggest that feedback inhibition of CLOCK-BMAL1 is mediated by time-dependent physic...

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Bibliografski detalji
Glavni autori: Lee, Yongjin, Chen, Rongmin, Lee, Hyeong-min, Lee, Choogon
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044960/
https://ncbi.nlm.nih.gov/pubmed/21199878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.207217
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